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- W2389709418 abstract "Aim To study the regulatory effect of Yiqihuoxue medicine on myocardial macrophage migration inhibitory factor expression in rats with chronic heart failure.Methods The left coronary artery ligation in rats was used to establish myocardial infarction heart failure model.In the fourth week of experiment,echocardiography was used,and model rats were divided into 6 groups: Model,APS,Tan,APS+Tan,Atorvastatin and Sham group.Results After 6 weeks,the left ventricular histological analysis showed a decrease of myocardial cells,an increase of fibroblasts and inflammatory cells infiltration in the model group.RT-PCR assay suggested that MIFmRNA of the model group was significantly higher than the sham operation group(P0.05);ELISA assay suggested that the serum MIF,TNF-α,IL-6 of the model group were significantly higher than the sham group,drug groups could decrease the MIFmRNA expression and the serum levels(P0.05).Conclusion Yiqihuoxue medicine plays a role in the prevention and treatment on heart failure after myocardial infarction,which may inhibite the activation of MIF and reduce the expression of TNF-α and IL-6." @default.
- W2389709418 created "2016-06-24" @default.
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- W2389709418 date "2011-01-01" @default.
- W2389709418 modified "2023-09-23" @default.
- W2389709418 title "Regulatory effect of astragalan and salviol on macrophage migration inhibitory factor expression in rats with chronic heart failure" @default.
- W2389709418 hasPublicationYear "2011" @default.
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