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- W2389709626 abstract "Objective:The present study was designed to observe the effect of Paeornla Licore Tang(PR/L) and its disassembled formula Shaoyao(PR),Ganchao(L) on damage of rat IEC-6 cells induced by H2O2,and also to investigate the potential mechanism.Method: IEC-6 cells were cultured with blank control medium,PR/L,PR,or L of the fixed dosages previously for 24 h,and then stimulated with 200 μmol · L-1 H2O2 for 2 h.Cell survival was measured by MTT assay.Cell apoptosis was evaluated by using flow cytometry with Annexin V / PI staining.Expression of Caspase-3 mRNA was detected by RT-qPCR.Result: Compared with the controls,the H2O2 model showed decrease in survival and expression of Caspase-3 mRNA,and increase in apoptosis.Compared with the H2O2 model,after treatment of PR 200 μg · mL-1 or 100 μg · mL-1,Gancao of 100 μg · mL-1 or 50 μg · mL-1,or both PR and L for 24 h,cell damage and cell apoptosis were reduced significantly,and expression of Caspase-3 mRNA and protein was both increased.Conclusion: Shaoyao,Gancao,and Shaoyao Ganchao Tang can protect IEC-6 cells from damage by H2O2,which may be due to the decrease in Caspase-3 expression." @default.
- W2389709626 created "2016-06-24" @default.
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- W2389709626 date "2012-01-01" @default.
- W2389709626 modified "2023-09-22" @default.
- W2389709626 title "Shaoyao Ganchao Tang and its Disassembled Formula Protects IEC-6 Cells from H_2O_2-induced Damage" @default.
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