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- W2389715881 abstract "Objective:To investigate the immune mechanism of 5-fluorouracil(5-Fu) and Octerotide(Oct)in the treatment of severe acute pancreatitis(SAP)and it’s kidney injury.Methods:55 male SAP rats induced by retrograde infusion of 5% sodium taurocholate into bilopancreatic duct were randomly divided into 3 groups:Normal saline group(n=17)were treatmented with normal saline infusion,Oct group(n=18):The first dose of Oct was 2μg/100g iv,then 0.2μg/(100g·h)continuous injection,5-Fu group(n=20):The dose of 5-Fu was 2mg/h×12h.Rats from each group were killed at 12h after opertation.The plasma levels of tumor necrosis factor-α(TNF-α),interleukin-1(IL-1)were assessed by ELISA method.Thromboxan B_2(TXB_2)and prostaglandinE_2(PGE_2)were assessed by radioimmunoassay method.The expression of TNF-α mRNA was detected by RT-PCR.The apoptosis rate of rat kidney tissue were detected by TUNEL method.Apoptosis rate of NRK cell treated by serum of different groups were assessed by flow cytometry methods.Results:The plasma level of TNF-α、IL-1 and TXB_2 in 5-Fu and Oct group were much lower than that in normal saline group.The expression of TNF-α mRNA of kidney tissue decreased significantly after the SAP was treated by 5-Fu or octreotide.The apoptosis rate of NRK cell disposed by normal saline group,oct group,5-Fu group and control group rat plasma were (38.67±11.4)%,(20.4±18.4)%,(10.5±11.0)% and (1.7±2.2)% respectively(P0.05 respectively).Conclusion:5-Fu and Octreotide are effective in the treatment of SAP.The mechanism may related with the inhibition of plasma cytokines and inflammation mediator such as TNF-α in the kidney tissue and the protection of kidney cells from apoptosis." @default.
- W2389715881 created "2016-06-24" @default.
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- W2389715881 date "2006-01-01" @default.
- W2389715881 modified "2023-09-23" @default.
- W2389715881 title "The immune mechanism of 5-fluorouracil in the protection of kidney from injury of severe acute pancreatitis" @default.
- W2389715881 hasPublicationYear "2006" @default.
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