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- W2389722081 abstract "【Objective】To investigate effects of smoking and smoking cessation on fibrosis, inflammation and oxidative stress in lung tissue of pulmonary interstitial fibrosis rats induced by Bleomycin.【Methods】56 healthy Wistar rats were randomly divided into four groups, control group; Bleomycin(BLM) group:intratracheal Bleomycin instillation; smoking BLM group:smoking after Bleomycin intervention; smoking -smoking cessation -BLM group: intratracheal Bleomycin instillation after smoking-smoking cessation, 14 rats each group. Seven rats in each group were executed at days 14 and 28 after intratracheal bleomycin instillation, collecting lung tissue slice for HE and Masson stain, determining lung tissue alveolitis and pulmonary fibrosis, observing the lever of malondialdehyde (MDA) in blood serum. 【Results】The success of the establishment of Bleomycin-induced pulmonary interstitial fibrosis model. The indicators change at corresponding groups and times. Compared with 14 days, the rat lung tissue of BLM group 28 days have heavier fibrosis, lighter inflammatory response,lower MDA. Compared with BLM group, smoking BLM group have lighter fibrosis, heavier inflammatory response,higher MDA. Compared with smoking BLM geoup,smoking -smoking cessation-BLM grpup have heavier fibrosis,higher MDA. 【Conclusion】Smoking aggravated inflammation and oxidation stress in pulmonary interstitial fibrosis rat lung tissue, but at the same time to reduce or delay fibrosis change." @default.
- W2389722081 created "2016-06-24" @default.
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- W2389722081 date "2009-01-01" @default.
- W2389722081 modified "2023-09-25" @default.
- W2389722081 title "Effects of smoking and smoking cessation on changes of inflammation and fibrosis in lung tissue of pulmonary interstitial fibrosis rats induced by Bleomycin" @default.
- W2389722081 hasPublicationYear "2009" @default.
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