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- W2389724107 abstract "Objective: To observe the antagonistic effect of Yinqiao Yupingfeng decoction on the immunosuppression in acute wind-cold stressed mice. Methods:[Kunming mice were divided into 5 groups at random: normal group (N), model group (M), Yupingfeng granules (YPF), high dosage Yinqiao Yupingfeng decoction (HYQYPF), low dosage Yinqiao Yupingfeng (LYQYPF). The animals were used in age of 8 to 10 weeks. The number of female mice was equal to that of male mice. Each group consisted of 7 to 9 mice. Mice had been bred and housed for 3 days before the beginning of every experiment. Each mouse was fed same volume boiled water or decoction by intragastric injection. A week later, the mice of model group and treatment groups were stressed by cold fluid mixture of water and ice (0±1)℃ for 8 minutes. Then the mice were placed in a wind-cold stress box for 3 hours. 3 days later, the mice were killed and immunologic function was assayed. Radio immunoassay (RIA) was used for plasma IL-2 concentration. The thymic weight index was calculated and the thymic microscopic structure was studied also. [WT5”HZ]Results: The thymic weight index of stressed mice decreased obviously (P0.001). There was acute pathological atrophy in the thyms of stressed mice. The serum IL-2 level, the peritoneal exudate macrophage function, the responsiveness of peripheral lymphocyte to PHA decreased significantly. YPF, HYQYPF, LYQYPF all had protective effect on the immunologic function. Among the three decoctions, HYQYPF, LYQYPF showed the most obvious antagonist to immunosuppression. Conclusion: The immunosuppression caused by acute wind-cold stress is due to activating the pothalamopituitary-adrenal axis. YPF, HYQYPF, LYQYPF all could antagonize the immunosuppression of stressed mice. Among these, YQYPF (above all HYQYPF) has the most significant effect on the enhancement of immunologic function." @default.
- W2389724107 created "2016-06-24" @default.
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- W2389724107 date "2001-01-01" @default.
- W2389724107 modified "2023-09-23" @default.
- W2389724107 title "Experimental Study on Antagonistic Effect of Yinqiao Yupingfeng Decoction on Immunosuppression in Acute Wind-Cold Stressed Mice" @default.
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