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- W2389731664 abstract "AIM: To compare the effects of hypotensive and aggressive resuscitation strategies on blood loss,fluid requirements,hematocrit(Hct),tissue Na+-K+-ATPase and Ca2+-Mg2+-ATPase activities in a clinically relevant model of uncontrolled hemorrhagic shock in pregnancy rabbits.METHODS: Thirty anesthetized New Zealand white rabbits at mid and late gestation underwent uncontrolled hemorrhagic shock by transecting a small artery of mesometrium,followed by bleeding via carotid artery to mean arterial pressure(MAP) of 40-45 mmHg.Animals were randomly divided into five groups(n=6 each): sham shock(SS);shock without resuscitation(SH);aggressive resuscitation in pre-hospital phase with 4 mL/kg normal saline,followed by Ringer 's solution to MAP of 80 mmHg(NS),hypotensive resuscitation with 4 mL/kg of normal saline(NH) or hypertonic hydroxyl ethyl starch(7.5% NaCl + hydroxy ethyl starch,HHES,HHH) followed by Ringer 's solution to MAP of 60 mmHg.Finally,all the resuscitated animals received hemorrhage controlled and fully resuscitated to MAP of 80 mmHg.At the end of the experiment,survivors were sacrificed,skeletal muscle,cardiac muscle,liver,kidney,lung and ileum were harvested for determination of Na+-K+-ATPase and Ca2+-Mg2+-ATPase activities.RESULTS: Total blood loss and infused volume were compared between NH[(4.3±0.2)mL/kg,(47.2±4.1)mL/kg] and HHH[(4.1±0.3)mL/kg,(44.9±4.3)mL/kg] groups,both were significantly less than NS[(5.5±0.2)mL/kg,(65.5±3.8)mL/kg] group.Hct in NH(21.0%±2.1%) and HHH(21.5%±1.8%) were significantly higher than NS(14.2%±1.5%) and SH(12.5%±1.4%).Tissue Na+-K+-ATPase and Ca2+-Mg2+-ATPase activities were stimulated in all shock groups.Na+-K+-ATPase in skeletal muscle,cardiac muscle,liver,kidney was significantly lower in the NH(5.42±1.41,4.54±2.01,4.13±0.62,3.42±0.84) and HHH(3.97±0.91,2.94±0.66,3.22±1.42,3.03±0.53) than that in NS(7.34±1.41,6.23±1.53,6.11±0.97,5.82±0.69) and SH(9.11±0.52,8.40±1.08,7.04±1.13,6.55±1.45).CONCLUSION: Hypotensive resuscitation with normal saline or HHES reduces blood loss,decreses total infused volume,leads to higher hematocrit and finally alleviates metabolism derangement after uncontrolled hemorrhagic shock." @default.
- W2389731664 created "2016-06-24" @default.
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- W2389731664 date "2009-01-01" @default.
- W2389731664 modified "2023-09-24" @default.
- W2389731664 title "Effects of hypotensive or aggressive resuscitation on tissue ATPase activity in pregnant rabbits with uncontrolled hemorrhagic shock" @default.
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