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- W2389748941 abstract "hIL 2 gene and mIFN γ gene were linked with internal ribosome entry site (IRES)from polio viruses, then cloned into a single adeno associated virus vector plasmid pAC to construct a two gene vector pAC FRI. In vitro, MM45 T. Li cells were transfected with pAC FRI using Dosper. The expression of these two genes was proved by Northern blot analysis and assay of biological activity. In vivo , the two genes treatment and the single gene IL 2 or IFN γ treatment showed more significant anti tumor effect and higher specific CTL activity after the intratumoral injection of the Dosper DNA complexes as compared with the LacZ gene treatment." @default.
- W2389748941 created "2016-06-24" @default.
- W2389748941 creator A5078844871 @default.
- W2389748941 date "2000-01-01" @default.
- W2389748941 modified "2023-09-23" @default.
- W2389748941 title "Efficient Gene Transfer and Antitumor Effect of Adeno associated Virus based Plasmid Carrying of IL-2cDNA and IFN-γcDNA Complexed with Cationic Liposome" @default.
- W2389748941 hasPublicationYear "2000" @default.
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