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- W2389758413 abstract "[Objective] To investigate the efficacy and safety of Mizoribine (MZR, bredinin) versus Mycophenolate mofetil (MMF) as maintainance agent in Cyclosporine (CsA)-based immunosuppressive regime in kidney transplantation. [Methods] Twenty-eight cadaveric kidney allograft recipients (male/female 19/9) were involved. The donor kidneys were harvested en bloc and flushed through WMO-1 solution. Warm ischemic time was 3～7 minutes, and cold ischemic time was 5～16 hours. These patients were divided into 2 groups: (1) CsA +MZR (n=14): the patients received MZR at a initial dose of 1～2 mg/(kg·d) in combination with CsA and Corcosteriod. CsA+MMF (n=14): patients received the triple-combined regime with CsA, MMF (1.5～2 g/d) and Corcosteriod as primary immunosuppressants. [Results] There was no loss of grafts or patients in each group at 6 months follow-up. No significant difference (P 0.05) with respect to the episodes of acute rejection (1/14 in MMF group vs. 1/14 in MZR group) and mean serum creatinine level [(98.6±2.5) μmol/L in MMF group vs. (100.2±1.7) μmol/L in MZR group] were observed. The incidence of gastrointestinal dysfunction and leukopenia were comparable. Nevertheless, 2 cases in MZR group underwent transient hyperglycemia probably due to high-dose Corcosteriod. [Conclusion] MZR is a potent immunosuppressant with lower hepatic toxicity. Instead of MMF, MZR could be used effectively as maintainable agent in Cyclosporine-based regime in kidney transplantation." @default.
- W2389758413 created "2016-06-24" @default.
- W2389758413 creator A5090780152 @default.
- W2389758413 date "2006-01-01" @default.
- W2389758413 modified "2023-09-22" @default.
- W2389758413 title "Prospective trial of Mizoribine versus Mycophenolate mofetil in Cyclosporine-based kidney transplantation" @default.
- W2389758413 hasPublicationYear "2006" @default.
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