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- W2389762803 abstract "Objective To study the pathogeneses,the nature and the possible mechanism of malignant transformation of angioimmunoblastic lymphadenopathy(AIL), to investigate the expression of bcl 2,P53 proteins and bcl 2/IgH fusion gene. Methods Immunogenotype analysis and expression of bcl 2,P53 proteins were detected by immunohistochemistry,bcl 2/IgH fusion gene was detected by polymerase chain reaction(PCR)in 22 cases of AIL.20 cases of non Hodgkin's lymphomas and 10 cases of reactive lymphoproliferations were used for control. Results The possitive rates of bcl 2 and P53 protein in AIL were 63.6%(14/22) and 31.8%(7/22) respectively. bcl 2 and P53 protein positive expression showed significant difference between AIL and NHL cases( P 0.05).bcl 2 /IgH fusion gene was found in 1 case of AIL.This translocation was also found in 1 case of the reactive proliferations. Conclusion The results suggest that bcl 2 and P53 protein affect the apoptosis by different mechanism, and both are involved in the pathogenesis of AIL and malignant transformation. AIL may be a kind of clinical syndrome common to the diseases of different causes and natures. [" @default.
- W2389762803 created "2016-06-24" @default.
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- W2389762803 date "2000-01-01" @default.
- W2389762803 modified "2023-09-24" @default.
- W2389762803 title "THE EXPRESSION OF bcl-2 AND P53 PROTEINS IN ANGIOIMMUNOBLASTIC LYMPHADENOPATHY" @default.
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