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- W2389771823 abstract "Objective: To obverse the effects of hawthorn leaves flavonoids on the apoptosis rate of the islet βTC3 cells induced by free fatty acids(FFA),and its effective concentration was also investigated simultaneously.Methods: The research object used were the islet βTC3 cells,and palmic acid was used to produce lipotoxicity model.The inhibitory actions of FFA on the proliferation of islet βTC3 cells were observed by using MTT assay and the effective concentration of hawthorn leaves flavonoids and treat time were investigated in details.The apoptosis rate of the cells was detected by TUNEL method.Results: The results obtained from MTT indicated that the hawthorn leaves flavonoids could effectively inhibit the lipotoxicity of palmic acid,and its absorbance is greater than that of palmic acid groups(P0.05).On the other hand,the treatment of the 50 g/ml hawthorn leaves flavonoids together with palmic acid to the islet βTC3 cells for 24h was demonstrated to be the most effective in cell protection.The results of TUNEL shown that the apoptosis rate of the hawthorn leaves flavonoids and palmic acid group is lower than that of the palmic acid group.Conclusion: Hawthorn leaves flavonoids could bring an effective protection for the islet βTC3 cells during the stimulation by free fatty acids,and this protection is dependent on the concentration of the hawthorn leaves flavonoids." @default.
- W2389771823 created "2016-06-24" @default.
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- W2389771823 date "2012-01-01" @default.
- W2389771823 modified "2023-09-26" @default.
- W2389771823 title "Protective Effects of Hawthorn Leaves Flavonoids on Lipotoxicitic Apoptosis in Islet βTC3 Cells induced by Free Fatty Acid" @default.
- W2389771823 hasPublicationYear "2012" @default.
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