Matches in SemOpenAlex for { <https://semopenalex.org/work/W2389772267> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2389772267 endingPage "31" @default.
- W2389772267 startingPage "928" @default.
- W2389772267 abstract "To explore the role of p38 signal pathway in regulating matrix metalloproteinase-9 (MMP-9) expression and brain edema formation in a rat model of traumatic brain injury (TBI).A total of 130 adult male Sprague Dawley rats were randomly divided into 4 groups, namely the normal group (n=10), sham-operated group (n=40), TBI (induced by Feeney free falling methods) group (n=40), and SB group with intraperitoneal SB203580 treatment (10 µmol/L) 15 min before TBI (n=40). The rats were sacrificed 2 h and 2 days after TBI. The expressions of p38, p-p38, and MMP-9 mRNA and protein were detected by RT-PCR and Western blotting. The blood brain barrier permeability was detected by Evans Blue (EB) test, and the brain water content (BWC) was determined using a gravimetric technique.The expression of p-p38 protein increased markedly 2 h after TBI (P<0.05), and was suppressed by SB203580 treatment (P<0.05). MMP-9 mRNA and protein showed no obvious increase at 2 h after TBI, but significantly increased at 2 days as compared with those in the sham-operated group (P<0.05). MMP-9 mRNA and protein were much lower in SB group than in TBI group 2 days after TBI (P<0.05). The blood brain barrier permeability significantly increased 2 h after TBI (P<0.05) and kept increasing until 2 days (P<0.05), but was reduced significantly by SB203580 (P<0.05). BWC increased obviously 2 days after TBI (P<0.05) and was lessened by SB203580 (P<0.05).Blocking p38 signal pathway can attenuate MMP-9 upregulation and brain edema after TBI, suggesting the important role of p38 in regulating MMP-9 expression to affect traumatic brain edema." @default.
- W2389772267 created "2016-06-24" @default.
- W2389772267 creator A5016780203 @default.
- W2389772267 creator A5016917412 @default.
- W2389772267 creator A5030225520 @default.
- W2389772267 creator A5052578332 @default.
- W2389772267 creator A5068331812 @default.
- W2389772267 creator A5074339533 @default.
- W2389772267 date "2012-06-01" @default.
- W2389772267 modified "2023-09-23" @default.
- W2389772267 title "[Blocking p38 signal pathway lowers MMP-9 expression and reduces brain edema in rats with traumatic brain injury]." @default.
- W2389772267 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22820569" @default.
- W2389772267 hasPublicationYear "2012" @default.
- W2389772267 type Work @default.
- W2389772267 sameAs 2389772267 @default.
- W2389772267 citedByCount "2" @default.
- W2389772267 countsByYear W23897722672017 @default.
- W2389772267 countsByYear W23897722672018 @default.
- W2389772267 crossrefType "journal-article" @default.
- W2389772267 hasAuthorship W2389772267A5016780203 @default.
- W2389772267 hasAuthorship W2389772267A5016917412 @default.
- W2389772267 hasAuthorship W2389772267A5030225520 @default.
- W2389772267 hasAuthorship W2389772267A5052578332 @default.
- W2389772267 hasAuthorship W2389772267A5068331812 @default.
- W2389772267 hasAuthorship W2389772267A5074339533 @default.
- W2389772267 hasConcept C104317684 @default.
- W2389772267 hasConcept C105580179 @default.
- W2389772267 hasConcept C109523444 @default.
- W2389772267 hasConcept C118552586 @default.
- W2389772267 hasConcept C11960822 @default.
- W2389772267 hasConcept C126322002 @default.
- W2389772267 hasConcept C134018914 @default.
- W2389772267 hasConcept C185592680 @default.
- W2389772267 hasConcept C2777649898 @default.
- W2389772267 hasConcept C2778402981 @default.
- W2389772267 hasConcept C2780159080 @default.
- W2389772267 hasConcept C2780886150 @default.
- W2389772267 hasConcept C2781017439 @default.
- W2389772267 hasConcept C42219234 @default.
- W2389772267 hasConcept C51551487 @default.
- W2389772267 hasConcept C529278444 @default.
- W2389772267 hasConcept C55493867 @default.
- W2389772267 hasConcept C71924100 @default.
- W2389772267 hasConcept C85265743 @default.
- W2389772267 hasConcept C97029542 @default.
- W2389772267 hasConceptScore W2389772267C104317684 @default.
- W2389772267 hasConceptScore W2389772267C105580179 @default.
- W2389772267 hasConceptScore W2389772267C109523444 @default.
- W2389772267 hasConceptScore W2389772267C118552586 @default.
- W2389772267 hasConceptScore W2389772267C11960822 @default.
- W2389772267 hasConceptScore W2389772267C126322002 @default.
- W2389772267 hasConceptScore W2389772267C134018914 @default.
- W2389772267 hasConceptScore W2389772267C185592680 @default.
- W2389772267 hasConceptScore W2389772267C2777649898 @default.
- W2389772267 hasConceptScore W2389772267C2778402981 @default.
- W2389772267 hasConceptScore W2389772267C2780159080 @default.
- W2389772267 hasConceptScore W2389772267C2780886150 @default.
- W2389772267 hasConceptScore W2389772267C2781017439 @default.
- W2389772267 hasConceptScore W2389772267C42219234 @default.
- W2389772267 hasConceptScore W2389772267C51551487 @default.
- W2389772267 hasConceptScore W2389772267C529278444 @default.
- W2389772267 hasConceptScore W2389772267C55493867 @default.
- W2389772267 hasConceptScore W2389772267C71924100 @default.
- W2389772267 hasConceptScore W2389772267C85265743 @default.
- W2389772267 hasConceptScore W2389772267C97029542 @default.
- W2389772267 hasIssue "7" @default.
- W2389772267 hasLocation W23897722671 @default.
- W2389772267 hasOpenAccess W2389772267 @default.
- W2389772267 hasPrimaryLocation W23897722671 @default.
- W2389772267 hasRelatedWork W1572148708 @default.
- W2389772267 hasRelatedWork W1755360319 @default.
- W2389772267 hasRelatedWork W2042822864 @default.
- W2389772267 hasRelatedWork W2086474773 @default.
- W2389772267 hasRelatedWork W2124515088 @default.
- W2389772267 hasRelatedWork W2361909637 @default.
- W2389772267 hasRelatedWork W2391265053 @default.
- W2389772267 hasRelatedWork W2805218717 @default.
- W2389772267 hasRelatedWork W3118751308 @default.
- W2389772267 hasRelatedWork W3210244313 @default.
- W2389772267 hasVolume "32" @default.
- W2389772267 isParatext "false" @default.
- W2389772267 isRetracted "false" @default.
- W2389772267 magId "2389772267" @default.
- W2389772267 workType "article" @default.