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- W2389772570 abstract "Objective To summarize the clinical characteristics,magnetic resonance imaging(MRI)findings and treatment regimen in childhood hemophagocytic lymphohistiocytosis with central nervous system(CNS-HLH) involvement.Methods Clinical manifestations,cerebrospinal fluid(CSF) evaluations,brain MRI findings and prognosis in 3 CNS-HLH patients were reviewed retrospectively.Results ①CNS-HLH was found in severe cases(2 cases) or cases with progressive systemic symptoms(2 cases);②Clinical manifestations were mainly presented by headache,nausea,somnolence,coma and convulsions;③CSF examination showed elevated protein and pleocytosis.Hemophagocyte was found in 1 case.④Brain MRI indicated subdural fluid accumulation and increased intensity of focal brain parenchyma on T2 weighed image.⑤After treatment of VM26(150 mg/m2,once per week)and ATG 2.5 mg/kg.d for 5 days,2 patients obtained remission,and 1 patient was cured.Conclusions CNS-HLH often occurs in severe HLH cases,and develops progressively.Its clinical features,CSF findings and brain MRI results are aspecific.Strong cytokine storm could be controlled by immunosuppressants such as VM26 and ATG instead of HLH-2004 protocol,in order to earn more time for hematopoietic stem cell transplantation." @default.
- W2389772570 created "2016-06-24" @default.
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- W2389772570 date "2011-01-01" @default.
- W2389772570 modified "2023-09-23" @default.
- W2389772570 title "Clinical analysis of childhood hemophagocytic lymphohistiocytosis with CNS involvement" @default.
- W2389772570 hasPublicationYear "2011" @default.
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