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- W2389773991 abstract "[Objective] Study the relationship between the cerebral edema after cerebral hemorrhage and AQP4mRNA expression, and the interferent effect of hirudin and nimotop. [Methods] The ICH models were established by stereotaxic injecting of auto-non-anticoagulated artery blood into the caudate nucleus, detected AQP4mRNA expression by RT-PCR, and cerebral edema(cerebral water contents) after giving hirudin and nimotop. [Result] Compared with the controlled group, cerebral edema appeared in ICH group, hirudin group and nimotop group 6 h after cerebral hemorrhage (P 0.05), it reached peak at 3 d (P 0.05), increased to (82.13±0.36), (79.48±0.46) and (81.26±0.42) respectively, and cerebral edema of hirudin group, nimotop group were lower than cerebral hemorrhage group (P 0.05). AQP4mRNA expression reached peak at 3 d (P 0.05), and the levels were (1.34±0.14), (1.03±0.05) and (1.27±0.14) respectively. There was a significantly positive correlation between BBB permeability and AQP4mRNA. [Conclusions] AQP4mRNA expression increased significantly after cerebral hemorrhage, which suggested APQ4mRNA involved in pathogenesis and development of cerebral edema, and hirudin, nimotop could inhibit cerebral edema." @default.
- W2389773991 created "2016-06-24" @default.
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- W2389773991 date "2006-01-01" @default.
- W2389773991 modified "2023-09-25" @default.
- W2389773991 title "Effect of both hirudin and nimotop on AQP4mRNA expression and cerebral edema after experimental cerebral hemorrhage in rats" @default.
- W2389773991 hasPublicationYear "2006" @default.
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