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- W2389776027 abstract "An animal model of radiation-induced skin ulcer was set up with 140 rats, which were locally irradiated with 35~55Gy γ-rays. The pathological changes were observed for 1 year. Immunohistochemical studies were performed in 72 rat radiation skin ulcer specimens using anti-p53 and anti-MDM2 protein polyclonal antibodies. The results showed that the positive rate for overexpression of p53 protein was 9.7%, and for that of MDM2 was 19.4%. The overexpression of p53 was mainly seen in the nuclei of activated squamous epithelial cells, and in fibroblasts, endotheliocytes in deeper part of the skin ulcers. The overexpression of MDM2 had the same localizations. It's suggested that the changes of p53 and MDM2, genes and proteins, may be related to the cancer transformation and poor healing of radiation-induced skin ulcers." @default.
- W2389776027 created "2016-06-24" @default.
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- W2389776027 date "2000-01-01" @default.
- W2389776027 modified "2023-09-25" @default.
- W2389776027 title "OVEREXPRESSION OF p53, MDM2 PROTEINS IN SOME ATR RADIATION-IMDUCED SKIN ULCERS" @default.
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