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- W2389776421 abstract "Ginsenoside compound K(CK),20-O-β-(D-glucopyranosyl)-20(S)-protopanaxadiol,is a major form of protopanaxadiol type saponins absorbed by the human body after oral administration,and a real component that mediates pharmacologic actions.Recently,new progress has been made in studies on pharmacological actions:① CK can activate caspase 8,which plays a key role in CK-stimulated apoptosis via activation of caspase 3 directly or indirectly through mitochondria pathway and can regulate the metastasis and invasiveness of tumor cells by down-regulating metalloproteinase 9 gene expression;② CK can reduce expression levels of NO synthase and cyclooxygenase-2 and inhibit secretion of some pro-inflammatory cytokines like interleukin 4(IL-4),IL-6 or tumor necrosis factor-α,which are responsible for its anti-inflammatory,anti-allergic,and neuro-protective activities;③ CK can enhance the insulin secretion by blocking the ATP sensitive K+ channel,improve insulin sensitivity,and shift glucose metabolisim from hepatic glucose production to hepatic glucose utilization in the liver,suggesting that CK be a therapeutic reagent for type 2 diabetic patients;④ CK can prevent the ultraviolet radiation induced skin damage by up-regulating nucleotide excision repair gene expression." @default.
- W2389776421 created "2016-06-24" @default.
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- W2389776421 date "2011-01-01" @default.
- W2389776421 modified "2023-09-23" @default.
- W2389776421 title "Progress in pharmacological actions of ginsenoside compound K,an active metabolite of protopanaxadiol type saponins" @default.
- W2389776421 hasPublicationYear "2011" @default.
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