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- W2389777720 abstract "Objective To determine whether the polydafin ( POL) can inhibits the increase of intercellular free Calcium(Ca2+ )i induced by glutamate. Method All neurons are divided into three groups① give 1× 10- 5mol/Lglutamate for 20 seconds ,② give 1× 10- 5mol/L glutamate and 50μ g/ml( POL) at the same time for 20 seconds ,③ give 1× 10- 5mol/L glutamate after (Ca2+ )i② group return to the baseline. Result POL 50μ g/ml can obviously inhibits the increase of (Ca2+ )i induced by glutamate and it can also effect the time of Calcium oscillation, it can slow down the increase of (Ca2+ )i, fasten the decrease of(Ca2+ )i. Conclusion POL can effect the active of NMDA receptors and prevent neurou from glutamate neurotoxiticity through reduction the rise of(Ca2+ )i." @default.
- W2389777720 created "2016-06-24" @default.
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- W2389777720 date "2001-01-01" @default.
- W2389777720 modified "2023-09-25" @default.
- W2389777720 title "The reserch of polydafin protection on cerebral ischemia neurous" @default.
- W2389777720 hasPublicationYear "2001" @default.
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