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- W2389778052 abstract "Objective To observe the effect of activation of M3 receptor on H2O2 induced apoptosis in cultured rat myocytes and to investigate its possible mechanisms.Methods Made intervention with M3 receptor agonist and M3 receptor blocking pharmacon 4DAMP on the basis of the rat myocardial cell damage which induced by H2O2.The apoptosis in cardiomyocyte was detected by flow cytomery(FCM).The rererse transcnption-polymerase chain reaction detected the apoptosis-related Bcl-2 protein.Results H2O2-mediected myocyte apoptosis was attenuated by M3 receptor against choline;Retreatment of cardiac myocytes with choline also increased Bcl-2 expression;However,blockage of M3 receptor by 4DAMP completely inhibited these effects of choline on cardial myocytes.Conclusion Activation of M3 receptor showed protective effect on H2O2-induced apoptosis in cultured rat myocytes and this effect might be related to modulating the expression of the gene Bcl-2." @default.
- W2389778052 created "2016-06-24" @default.
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- W2389778052 date "2009-01-01" @default.
- W2389778052 modified "2023-09-22" @default.
- W2389778052 title "Experimental Investigation of M_3 Receptor to Myocardial Cytoprotection" @default.
- W2389778052 hasPublicationYear "2009" @default.
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