Matches in SemOpenAlex for { <https://semopenalex.org/work/W2389778508> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2389778508 abstract "Objective: To investigate the regulatory effects of Shufeng Xuanfei and Jiebiao Qingli Chinese medicine formulae on TLR3 /7 signal pathway in human pulmonary carcinoma cell A549. Methods: Gene chips were used to screen these RNA samples in virus- infected A549. Select differentially expressed genes of TLR3 /7 signal pathway. The mRNA and protein expressions of TLR3 /7,My D88,NF- κB were verified by Real- Time PCR and western- blot. Results:Tlr3,Tlr7,Myd88,Nfbk1,Mapk8,Mapk13,Ifna1 and Ifnβ1 were up- regulated in virus- infected group. Shufeng Xuanfei and Jiebiao Qingli formulae could down- regulate gene expressions of Tlr3,Tlr7,Myd88,Nfbk1,Mapk8,Mapk13,Ifna1 and Ifnβ1. Real- Time PCR and western blot experiments showed that two formulae could significantly decrease mRNA and protein expressions of TLR3 /7,My D88 and NF- κB( P 0. 01),compared with the virus- infected group. The results also figured that the interference efficacy of Shufeng Xuanfei formula was better than that of Jiebiao Qingli. As was expected,real- time PCR and western- blot data were in agreement with the microarray assay. Conclusion: Shufeng Xuanfei and Jiebiao Qingli formulae can down- regulate the activity of NF- κB by regulating My D88 in TLR3 /7 signal pathway,thus fighting against influenza virus in vitro." @default.
- W2389778508 created "2016-06-24" @default.
- W2389778508 creator A5020359808 @default.
- W2389778508 date "2015-01-01" @default.
- W2389778508 modified "2023-09-27" @default.
- W2389778508 title "Effect of Shufeng Xuanfei Formula and Jiebiao Qingli Formula on TLR3 /7 Signal Pathway in Human Pulmonary Carcinoma Cell A549 and Its Mechanism" @default.
- W2389778508 hasPublicationYear "2015" @default.
- W2389778508 type Work @default.
- W2389778508 sameAs 2389778508 @default.
- W2389778508 citedByCount "0" @default.
- W2389778508 crossrefType "journal-article" @default.
- W2389778508 hasAuthorship W2389778508A5020359808 @default.
- W2389778508 hasConcept C104317684 @default.
- W2389778508 hasConcept C105580179 @default.
- W2389778508 hasConcept C136449434 @default.
- W2389778508 hasConcept C150194340 @default.
- W2389778508 hasConcept C153911025 @default.
- W2389778508 hasConcept C159047783 @default.
- W2389778508 hasConcept C170493617 @default.
- W2389778508 hasConcept C2522874641 @default.
- W2389778508 hasConcept C2776415932 @default.
- W2389778508 hasConcept C2776709828 @default.
- W2389778508 hasConcept C2778420691 @default.
- W2389778508 hasConcept C48023723 @default.
- W2389778508 hasConcept C54355233 @default.
- W2389778508 hasConcept C55493867 @default.
- W2389778508 hasConcept C81729549 @default.
- W2389778508 hasConcept C81885089 @default.
- W2389778508 hasConcept C86803240 @default.
- W2389778508 hasConceptScore W2389778508C104317684 @default.
- W2389778508 hasConceptScore W2389778508C105580179 @default.
- W2389778508 hasConceptScore W2389778508C136449434 @default.
- W2389778508 hasConceptScore W2389778508C150194340 @default.
- W2389778508 hasConceptScore W2389778508C153911025 @default.
- W2389778508 hasConceptScore W2389778508C159047783 @default.
- W2389778508 hasConceptScore W2389778508C170493617 @default.
- W2389778508 hasConceptScore W2389778508C2522874641 @default.
- W2389778508 hasConceptScore W2389778508C2776415932 @default.
- W2389778508 hasConceptScore W2389778508C2776709828 @default.
- W2389778508 hasConceptScore W2389778508C2778420691 @default.
- W2389778508 hasConceptScore W2389778508C48023723 @default.
- W2389778508 hasConceptScore W2389778508C54355233 @default.
- W2389778508 hasConceptScore W2389778508C55493867 @default.
- W2389778508 hasConceptScore W2389778508C81729549 @default.
- W2389778508 hasConceptScore W2389778508C81885089 @default.
- W2389778508 hasConceptScore W2389778508C86803240 @default.
- W2389778508 hasLocation W23897785081 @default.
- W2389778508 hasOpenAccess W2389778508 @default.
- W2389778508 hasPrimaryLocation W23897785081 @default.
- W2389778508 hasRelatedWork W20176790 @default.
- W2389778508 hasRelatedWork W2047029865 @default.
- W2389778508 hasRelatedWork W2183795683 @default.
- W2389778508 hasRelatedWork W2416236444 @default.
- W2389778508 hasRelatedWork W2502488731 @default.
- W2389778508 hasRelatedWork W2681429388 @default.
- W2389778508 hasRelatedWork W2756401267 @default.
- W2389778508 hasRelatedWork W2757200532 @default.
- W2389778508 hasRelatedWork W2805852779 @default.
- W2389778508 hasRelatedWork W2806642605 @default.
- W2389778508 hasRelatedWork W2900233137 @default.
- W2389778508 hasRelatedWork W2986883375 @default.
- W2389778508 hasRelatedWork W3021821053 @default.
- W2389778508 hasRelatedWork W3026610757 @default.
- W2389778508 hasRelatedWork W3028741206 @default.
- W2389778508 hasRelatedWork W3028992916 @default.
- W2389778508 hasRelatedWork W3030236426 @default.
- W2389778508 hasRelatedWork W3083945116 @default.
- W2389778508 hasRelatedWork W3161619891 @default.
- W2389778508 hasRelatedWork W2772376840 @default.
- W2389778508 isParatext "false" @default.
- W2389778508 isRetracted "false" @default.
- W2389778508 magId "2389778508" @default.
- W2389778508 workType "article" @default.