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- W2389778885 abstract "Objective: To investigate the mechanism of Weichangshu promots gastrointestinal motility.Methods: Primary culture gastrointestinal smooth muscle cells,experiment was divided into Weichangshu high-dose group,Weichangshu middle-dose group,Weichangshu low-dose group,Cisapride group,and normal control group,tested drugs were used in each group interfere with cell 24h,detect the release of NO using Flow cytometry.Then extract the total RNA of cells,use reverse transcription-polymerase chain reaction,semi-quantitative analysis the changes of the expression of eNOS mRNA levels in gastrointestinal smooth muscle cells.Results: Compared with the normal control group,fluorescence intensity of NO release significantly reduced(P0.01,P0.05),and eNOS mRNA expression was significantly lower(P0.01,P0.05) of gastrointestinal smooth muscle cells in Weichangshu high-dose group and the middle-dose group.Conclusion: The mechanism of Weichangshu gastrointestinal motility-promoting was may be inhibiting the release of intracellular NO by inhibiting the expression of eNOS mRNA in gastrointestinal smooth muscle cells,and then inhibiting the activation of enzymes,antagonized the formation of cGMP,thus increasing intracellular Ca2+,Ca2+ signaling system triggered a series of physiological functions,thereby promoting effects of gastrointestinal smooth muscle contraction." @default.
- W2389778885 created "2016-06-24" @default.
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- W2389778885 date "2011-01-01" @default.
- W2389778885 modified "2023-09-27" @default.
- W2389778885 title "Effect of Weichangshu on release of nitrogen monoxidum and mRNA expression of endothelial nitricoxide synthase in gastrointestinal smooth muscle cells" @default.
- W2389778885 hasPublicationYear "2011" @default.
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