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- W2389784632 abstract "Objective To study the safflower yellow on myocardial connexin expression in mice with doxorubicininduced cardiotoxicity. Methods SPF Kunming mice were randomly divided into 5 groups, namely normal control group, model group, and high-, middle-and low-dose Chinese medicine groups. The mice of normal control group were given intraperitoneal injection of normal saline every day, and the mice of other groups were given intraperitoneal injection of doxorubicin 3 mg / kg, once every other day. Meanwhile, the model group was given intraperitoneal injection of normal saline, and high-, middle-and low-dose Chinese medicine groups were given intraperitoneal injection of safflower yellow(in the dosage of 10, 5, 2.5 g·kg-1·d-1, respectively). On the 15th day, left ventricular tissue in mice was sampled for the observation of myocardial pathological changes under light microscope by HE staining. The expression level of connexin 43( Cx43) in cardiac muscle was measured by streptavidin-biotin-peroxidase complex(SABC) method. Results Obvious myocardial injury was found, and the expression level of Cx43 in cardiac muscle of the model group was decreased as compared with those of the normal control group(P0.05). High-and middle-dose Safflower yellow groups had protection on myocardial injury induced by Doxorubicin and could increase the Cx43 expression level(P0.05), while low dose of safflower yellow group had no obvious anti-myocardial injury effects. Conclusion Safflower yellow exerts certain protective effect on doxorubicin-induced cardiotoxicity, and its mechanism may be related with the up-regulation of cardiac connexin expression." @default.
- W2389784632 created "2016-06-24" @default.
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- W2389784632 date "2014-01-01" @default.
- W2389784632 modified "2023-09-26" @default.
- W2389784632 title "Effect of Safflower Yellow on Myocardial Connexin Expression in Mice with Doxorubicin-induced Cardiotoxicity" @default.
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