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- W2389788659 abstract "Objective To investigate the localization of ZNT1 in Alzheimer's diseased (AD)brain, and to explore the possible role of ZNT1 in AD pathogenesis. Methods Immunohistochemistry, immunofluorescence and confocal laser scanning microscopy were used to analyze the distributions of ZNT1 and β-amyloid protein(Aβ)and the relationship between these two proteins in AD brain. Results ZNT1 immunoreactive product was seen to be localized in the senile plaques within the cerebral cortex of AD patients.Almost all of Aβ senile plaques presented ZNT1 immunoreactivity with different expression levels.Confocal microscopic results revealed that a colocalization of ZNT1 and Aβ was found in the senile plaques. Conclusion The abundant expression of ZNT1 in Aβ plaques suggests that ZNT1 may be involved in the formation of Aβ senile plaque in AD brain." @default.
- W2389788659 created "2016-06-24" @default.
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- W2389788659 date "2007-01-01" @default.
- W2389788659 modified "2023-09-23" @default.
- W2389788659 title "The Localization of ZincTransporter1(ZNT1) in Alzheimer's Disease Brain" @default.
- W2389788659 hasPublicationYear "2007" @default.
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