Matches in SemOpenAlex for { <https://semopenalex.org/work/W2389798660> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2389798660 abstract "Objective To investigate the effect of Angong Niuhuang Bolus(ANB) on mRNA expression of high mobility group box-1(HMGB1) protein and myeloperoxidase activity in the lung of rats with sepsis induced by cecal ligation and puncture(CLP) method.Methods Seventy-five male SD rats were randomly divided into normal control group,model group,AG490(a Janusk kinase inhibitor) treatment group(subcutaneous injection of AG490 8mg/kg 0.5 h before CLP),rapamycin(RPM,a signal transduction and transcription activator inhibitor) treatment group(subcutaneous injection of RPM 0.4 mg/kg 0.5 h before CLP),and low-,middle-and high-dose ANB groups(gastric gavage of ANB in the dose of 1.0,2.0 and 3.0 g·kg-1·d-1 respectively).The animals were sacrificed 24h after CLP,and then lung tissue samples were collected to determine the expression of HMGB1 mRNA by the method of reverse transcription polymerase chain reaction(RT-PCR).Meanwhile,the activity of pulmonary myeloperoxidase(MPO) was also measured.Results Compared with the normal control group,the mRNA expression of HMGB1 was significantly enhanced(P 0.01) and pulmonary MPO activity was markedly increased(P 0.05) in the model group.Compared with the model group,HMGB1 mRNA expression was significantly down-regulated in AG490 group,RPM group,and low-,middle-and high-dose ANB groups(P 0.01),and pulmonary MPO activity was decreased in AG490 group,RPM group,and low-and middle-dose ANB groups(P 0.05 or P 0.01).Conclusion ANB can down-regulate pulmonary HMGB1 mRNA expression,decrease pulmonary MPO activity,and reduce acute lung injury induced by abdominal infection,which has an effect similar to AG490 and RPM for the treatment of sepsis in rats." @default.
- W2389798660 created "2016-06-24" @default.
- W2389798660 creator A5059431543 @default.
- W2389798660 date "2010-01-01" @default.
- W2389798660 modified "2023-09-23" @default.
- W2389798660 title "Effect of Angong Niuhuang Bolus on High Mobility Group Box-1 Protein Expression and Myeloperoxidase Activity in Lung of Sepsis Rats" @default.
- W2389798660 hasPublicationYear "2010" @default.
- W2389798660 type Work @default.
- W2389798660 sameAs 2389798660 @default.
- W2389798660 citedByCount "0" @default.
- W2389798660 crossrefType "journal-article" @default.
- W2389798660 hasAuthorship W2389798660A5059431543 @default.
- W2389798660 hasConcept C104317684 @default.
- W2389798660 hasConcept C105580179 @default.
- W2389798660 hasConcept C126322002 @default.
- W2389798660 hasConcept C134018914 @default.
- W2389798660 hasConcept C16685009 @default.
- W2389798660 hasConcept C170493617 @default.
- W2389798660 hasConcept C185592680 @default.
- W2389798660 hasConcept C203565725 @default.
- W2389798660 hasConcept C2776390293 @default.
- W2389798660 hasConcept C2776914184 @default.
- W2389798660 hasConcept C2777714996 @default.
- W2389798660 hasConcept C2778384902 @default.
- W2389798660 hasConcept C2780545709 @default.
- W2389798660 hasConcept C30683889 @default.
- W2389798660 hasConcept C43376680 @default.
- W2389798660 hasConcept C4692481 @default.
- W2389798660 hasConcept C55493867 @default.
- W2389798660 hasConcept C71924100 @default.
- W2389798660 hasConceptScore W2389798660C104317684 @default.
- W2389798660 hasConceptScore W2389798660C105580179 @default.
- W2389798660 hasConceptScore W2389798660C126322002 @default.
- W2389798660 hasConceptScore W2389798660C134018914 @default.
- W2389798660 hasConceptScore W2389798660C16685009 @default.
- W2389798660 hasConceptScore W2389798660C170493617 @default.
- W2389798660 hasConceptScore W2389798660C185592680 @default.
- W2389798660 hasConceptScore W2389798660C203565725 @default.
- W2389798660 hasConceptScore W2389798660C2776390293 @default.
- W2389798660 hasConceptScore W2389798660C2776914184 @default.
- W2389798660 hasConceptScore W2389798660C2777714996 @default.
- W2389798660 hasConceptScore W2389798660C2778384902 @default.
- W2389798660 hasConceptScore W2389798660C2780545709 @default.
- W2389798660 hasConceptScore W2389798660C30683889 @default.
- W2389798660 hasConceptScore W2389798660C43376680 @default.
- W2389798660 hasConceptScore W2389798660C4692481 @default.
- W2389798660 hasConceptScore W2389798660C55493867 @default.
- W2389798660 hasConceptScore W2389798660C71924100 @default.
- W2389798660 hasLocation W23897986601 @default.
- W2389798660 hasOpenAccess W2389798660 @default.
- W2389798660 hasPrimaryLocation W23897986601 @default.
- W2389798660 hasRelatedWork W2051155495 @default.
- W2389798660 hasRelatedWork W2166097436 @default.
- W2389798660 hasRelatedWork W2347146973 @default.
- W2389798660 hasRelatedWork W2351617723 @default.
- W2389798660 hasRelatedWork W2352482062 @default.
- W2389798660 hasRelatedWork W2354346786 @default.
- W2389798660 hasRelatedWork W2356047737 @default.
- W2389798660 hasRelatedWork W2361389045 @default.
- W2389798660 hasRelatedWork W2374047225 @default.
- W2389798660 hasRelatedWork W2374123315 @default.
- W2389798660 hasRelatedWork W2380271996 @default.
- W2389798660 hasRelatedWork W2386179337 @default.
- W2389798660 hasRelatedWork W2386335000 @default.
- W2389798660 hasRelatedWork W2391778312 @default.
- W2389798660 hasRelatedWork W2398953444 @default.
- W2389798660 hasRelatedWork W2412933461 @default.
- W2389798660 hasRelatedWork W3008814980 @default.
- W2389798660 hasRelatedWork W3029065064 @default.
- W2389798660 hasRelatedWork W3031006501 @default.
- W2389798660 hasRelatedWork W3031831092 @default.
- W2389798660 isParatext "false" @default.
- W2389798660 isRetracted "false" @default.
- W2389798660 magId "2389798660" @default.
- W2389798660 workType "article" @default.