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- W2389804508 abstract "Objective:To explore the mechanism of effects of bruceolic oil emulsion,a traditional Chinese medicine,on prostatic carcinoma.Methods:11 cases(experimental group)with prostatic carcinoma during stage C and D were treated by orchiectomy+flutamide+bruceolic oil emulsion,and another 6 ones(control group)with prostatic carcinoma during stage C and D were treated by orchiectomy and single flutamide.Before and after the treatment,the samples of their prostatic tissue were collected by puncturation and the ultrastructure of prostatic carcinoma cell was observed under transmission electron microscope.At the same time,the level of serum prostate specific antigen(PSA)was measured before and after the treatment.Results:It was found that bruceolic oil emulsion could break the membrane system of the cancer cell,including mitochondria membrane,endoplasmic reticulum and nuclear membrane,and make cancer cell apoptosis and necrosis.After the treatment,the level of serum PSA of the experimental group(11.32±3.12 ng/ml)was higher than that of the control group(18.87±2.86 ng/ml)(P0.05).Conclusion:Bruceolic oil emulsion kills prostatic carcinoma cell by means of breaking membrane system of cancer cell and it can decrease the level of serum PSA." @default.
- W2389804508 created "2016-06-24" @default.
- W2389804508 creator A5061871132 @default.
- W2389804508 date "2007-01-01" @default.
- W2389804508 modified "2023-09-23" @default.
- W2389804508 title "Effects of bruceolic oil emulsion on ultrastructure of prostatic carcinoma cell and PSA" @default.
- W2389804508 hasPublicationYear "2007" @default.
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