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- W2389804512 abstract "Objective: To investigate the changes of the gene expression profile of rat liver tissue injured by co-administration of isoniazid( INH) and rifampicin( RFP) using cDNA microarrays. Methods: Twenty Wistar rats were divided into 2 groups( 10 in each group),and administrated( ig) with the combination of INH( 400mg·kg- 1) and RFP( 100 mg·kg- 1) or equal-volume saline,respectively,for 14 days. The gene expression profiles were detected by cDNA microarrays. The differentially expressed genes significantly correlated with liver injury were screened and analyzed. The mechanisms of liver injury caused by co-administration of INH and RFP were specifically analyzed at level of gene expression based on the biological functions of those differentially expressed genes. Results: Totally 55 differentially expressed genes were found in the rats with the combination of INH and RFP. Among them,36 genes were up-regulated,while the other 19 genes were down-regulated. These differential-ly expressed genes were functionally related to the changes in CYP450-related genes,and the genes relevant to the metabolism of three substances( glucose,protein,and lipid),liver function and antioxidation. Conclusion: The combination of INH and RFP causes the remarkable changes of the gene expression profiles in rat liver,which is important for further elucidating the mechanisms of liver injury caused by co-administration of INH and RFP." @default.
- W2389804512 created "2016-06-24" @default.
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- W2389804512 date "2015-01-01" @default.
- W2389804512 modified "2023-09-26" @default.
- W2389804512 title "Gene expression profile in injured rat liver induced by isoniazid and rifampicin using cDNA microarray" @default.
- W2389804512 hasPublicationYear "2015" @default.
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