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- W2389804549 abstract "Objective: To investigate the molecular mechanism of estrogen to prevent osteoporosis in ovariectomized (OVX) rats through examining osteoprotegerin (OPG) mRNA expression in lumbar vertebra.Methods:Thirty-six female Spague-Dauley rats aged 3 months were divided into three groups:OVX + Estrogen-Premarin(EP),OVX+Saline(OVX)and Sham-OVX Control (SHAM) with 12 rats in each group.All rats were sacrificed at 12 weeks after surgery and specimens of the third lumbar vertebrae were procured for total RNA extraction using single-step method by acid guanidinium thiocyanate-phenol-chloroform.Nested reverse transcriptase polymerase chain reaction (NRT-PCR) was applied to amplify OPG mRNA and its gene expression was examined in each group.Meanwhile,the fourth lumbar vertebrae were processed for histomorphometric analysis.Results:Of 12 lumbar vertebrae,10 in EP(83.3%) showed positive OPG mRNA expression,while only 2 in OVX(16.7%) expressed OPG mRNA positively.All the specimen in SHAM showed positive OPG mRNA expression.X 2 test revealed that there was highly significant difference existing between EP and OVX( P0.01 ).However,no significant difference was found between EP and SHAM ( P0.05 ).Parameters of bone histomorphometric analysis showed that BV/TV,Tb.Th.and TN in OVX were evidently lower but Tb.Sp.greater than in SHAM.In comparison with OVX,EP significantly increased BV/TV and Tb.Th.Although EP also decreased Th.Sp.,no statistic difference was found between EP and OVX.EP did not produce distinct effect on TN.Conclusion:Estrogen can effectively prevent osteoporosis in ovariectomized rats by up-regulating OPG mRNA expression and inhibiting osteoclastic bone resorption in concellous bone." @default.
- W2389804549 created "2016-06-24" @default.
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- W2389804549 date "2003-01-01" @default.
- W2389804549 modified "2023-09-23" @default.
- W2389804549 title "Effect of Estrogen on OPG mRNA Expression in Cancellous Bone of Ovariectomized Rats" @default.
- W2389804549 hasPublicationYear "2003" @default.
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