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- W2389842463 abstract "Objective To study the effects of orthosiphon extract on the kidney of chronic renal failure(CRF) in rat.Methods The study was carry our by using animal modol of rat kidney of chronic renal failure induced by adenine,there are five groups:Control group,CRF group,CRF plus high orthosiphon extract group,CRF plus low orthosiphon extract group,control plus Niaoduqing group.The experimental animals of 2-5 group were perfused with adenine for 18 days,then the serum BUN,Cr,UA,Hb,UMA,TNF-αlevel and the UTP of 24h urine were measured,which confirmed that Rat model of chronic renal failure was achieved.The 3rd and 4th group were treated with orthosiphon extract,the 5th group with Niaoduqing,the 1st and 2nd group with normal saline solution for 30 days.Then 24h urine of all rats was collected,besides,all rats were executed following a blood collecting and a kidney extraction.The weight of kidney and body were measured.The serum BUN,Cr,Hb,UMA,UA,TNF-α,Ca,P level and UTP of 24h urine were also measured.The morphological structure of kidney were observed by HE staining.Results Compared with the CRF group and control plus Niaoduqing group,the functional parameters of kidney were significantly different in the treated groups.TNF-α of treated groups decreased significantly in chronic renal failure(CRF) rat,significantly inhibiting the proliferation of renal intercapillary cells and matrix and attenuating the injury of the renal tubule and interstitium.Conclusion Orthosiphon extract can decrease the level of UTP,Cr,BUN,UA,UMA,TNF-α,P and increase the level of Hb,Ca in CRF rat.It can improve effectively the renal function and immunological function." @default.
- W2389842463 created "2016-06-24" @default.
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- W2389842463 date "2011-01-01" @default.
- W2389842463 modified "2023-09-22" @default.
- W2389842463 title "Preventing and Curing Chronic Renal Failure in Rat with Orthosiphon Extract:An Experimental Study" @default.
- W2389842463 hasPublicationYear "2011" @default.
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