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- W2389849096 abstract "Objective To determine whether canonical transient receptor potential channel(TRPC) is involved in SNPinduced apoptosis of the primary cultured rat hippocampal neurons via PUMA.Methods The cultured rat hippocampal neurons were treated with SNP.The expression of TRPC1-6 in hippocampal neurons were detected using RT-PCR.The expression level of Bax,Apaf-1,survivin and PUMA mRAN in hippocampal neurons were detected using Real-time RT-PCR.Results TRPCs were widely expressed in hippocampal neurons.The hippocampal neurons were treated with SNP for 4 h,8 h and 24 h,and SNP had no effect on the expression of Bax,Apaf-1 and survivin mRNA(P0.05);However,the expression level of PUMA was significantly increased to 1.94(4 h),1.86(8 h) and 1.9-fold(24 h)(P0.01).TRPC blocker(2-APB) was found to lower the elevated expression of PUMA(P0.01).Conclusion TRPC channels are involved in SNP-induced apoptosis of cultured rat hippocampal neurons via PUMA." @default.
- W2389849096 created "2016-06-24" @default.
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- W2389849096 date "2012-01-01" @default.
- W2389849096 modified "2023-09-28" @default.
- W2389849096 title "Requirement of TRPC ion channel in NO-induced apoptosis in hippocampal neurons via PUMA" @default.
- W2389849096 hasPublicationYear "2012" @default.
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