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- W2389849215 abstract "Objective To investigate the assemble character of family,risk of cancer,follow-up for the patients,the surgical treatment and the susceptible genes on Peutz-Jeghers Syndrome(PJS).Methods Retrospective analysis was made of 36 cases collected from 10 PJS families during 1994 to 2002.The operation treatment on 18 cases and the mutations of tumour susceptible genes in 15 cases were also analyzed.Results Thirty-three patients( 96.10%) had family history.The diagnosis age was from 3 months to 63 years old.The canceration rate was 44.44%(16/36).The priority part of canceration was colon.In our 18 cases,the polyps were mainly distributed in small intestine,then in colon and stomach,all were adenoma polyps.In 15 cases,13 cases had points mutation of serine /threonine kinase 11(STK11) gene,and 2 cases of canceration had lost exon 8 of fragile histidine triad(FHIT) gene.Conclusion The colon polyp of PJS has high risk of cancer.The patients of PJS could be screened changes of tumour susceptible genes,and they should be followed up and called back regularly in order to make a diagnosis and given treatment at early stage.So the patients may reduce or control the possibility of the polyp risk of cancer." @default.
- W2389849215 created "2016-06-24" @default.
- W2389849215 creator A5056798524 @default.
- W2389849215 date "2004-01-01" @default.
- W2389849215 modified "2023-09-23" @default.
- W2389849215 title "Analysis on 36 cases of Peutz-Jeghers Syndrome" @default.
- W2389849215 hasPublicationYear "2004" @default.
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