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- W2389853102 abstract "OBJECTIVE: To discuss the promoter methylation of estrogen receptor-alpha in sporadic basal-like breast cancer.METHODS: The methylation of ERα promoter was investigated in genomic DNA of 60 sporadic basal-like breast cancer by methylation-specific polymerase chain reaction.The correlation between ERα methylation and clinicopathological features of basal-like breast cancer was analyzed.RESULTS: ERα methylation was observed in 48 of 60(80.0%) sporadic basal-like breast cancer.No correlation was found between the ERα methylation and age,menopausal status,while it was significantly associated with lymph node metastasis,tumor stage,nuclear p53 accumulation,BRCA-1 and BRCA-2 expression in sporadic basal-like breast cancer.CONCLUSION: ERα methylation maybe plays an important role in basal-like breast carcinogenesiss." @default.
- W2389853102 created "2016-06-24" @default.
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- W2389853102 date "2012-01-01" @default.
- W2389853102 modified "2023-09-26" @default.
- W2389853102 title "Estrogen receptor-alpha promoter methylation in sporadic basal-like breast cancer" @default.
- W2389853102 hasPublicationYear "2012" @default.
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