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- W2389867858 abstract "Objective:To explore the optimal dose and the best time of flurbiprofen axetil pretreatment on propofol injection pain and to evaluate the safety of flurbiprofen axetil injection combined with propofol injection.Method:The incidences and severities of injection pain were compared in each group.The safety of those injections were evaluated by conducting injection site irritation test,active systemic anaphylaxis test,conventional in vitro hemolysis test.Result:Compared with saline intravenous injection,0.75,1 mg/kg flurbiprofen axetil intravenous injection + tourniquet venous occlusion for 2 min both obviously decreased the incidence and severity of injection pain,and there was no statistically significant difference between the two groups(P0.05).The incidences and severities of injection pain of 0.75 mg/kg flurbiprofen axetil and 1.5 mg/kg propofol mixture intravenous injection group and 0.75 mg/kg flurbiprofen axetil intravenous injection + tourniquet venous occlusion for 2 min group didn't have significant differences and were better than the 0.75 mg/kg flurbiprofen axetil intravenous injection + tourniquet venous occlusion for 1 min group;the incidence and severity of propofol injection pain of propofol immediate injection after 0.75 mg/kg flurbiprofen axetil intravenous injection was highest.There were no hyperemia,bleeding,swelling,necrosis and other abnormal in the injection site in those groups.The guinea rats were not symptoms of allergic reactions and no deaths.They all didn't cause rabbit erythrocyte hemolysis or cohesion.Conclusion:In the prevention of propofol injection pain,0.75 mg/kg flurbiprofen axetil + tourniquet venous occlusion for 2 min is able to achieve ideal analgesic effect;the effect of 0.75 mg/kg flurbiprofen axetil and 1.5 mg/kg propofol mixture intravenous injection is same as 0.75 mg/kg flurbiprofen axetil intravenous injection + tourniquet venous occlusion for 2 min,and better than 0.75 mg/kg flurbiprofen axetil intravenous injection + tourniquet venous occlusion for 1 min.Flurbiprofen axetil injection,propofol injection and flurbiprofen axetil injection combined with propofol injection don't have apparente irritation,allergic,haemolyticus." @default.
- W2389867858 created "2016-06-24" @default.
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- W2389867858 date "2014-01-01" @default.
- W2389867858 modified "2023-09-26" @default.
- W2389867858 title "The Clinical Research and Safety Evaluation of Flurbiprofen Axetil Pretreatment on Propofol Injection Pain" @default.
- W2389867858 hasPublicationYear "2014" @default.
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