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- W2389875494 abstract "ObjectiveTo investigate the influence of anti-tumor effect of Tiopronin combined with Oxaliplatin on a nude mouse model of human gastric carcinoma(HGC).MethodsA model of subcutaneous-transplanted HGC was created in nude mice,which were randomized to six groups with 10 mice in each group.Group A: 50 g/L glucose;group B:Oxaliplatin 6 mg/kg;group C:Tiopronin 30 mg/kg;group D:Oxaliplatin 6 mg/kg + Tiopronin 30 mg/kg;group E:Oxaliplatin 6 mg/kg + Tiopronin 45 mg/kg;group F:Oxaliplatin 6 mg/kg + Tiopronin 60 mg/kg.All the drugs were given through an intraperitoneal injection,once a day and continuous for 14 days.The weight of the mice and the volume of tumor were detected,the oncostatic rate was calculated,blood routine,liver and kidney functions were checked,and liver,kidney and tumor tissues were examined histologically.ResultsThe weight of mice in groups B,D,E,and F decreased in different extents after medication,as compared with that before,the differences were significant(t=5.52-9.74,P0.01),which showed a significant anti-tumor action;compared with group A,the difference was significant in terms of volume of tumor(F=130.77,t=8.58-18.94,P0.01);whereas the difference of anti-tumor action between groups D,E and groups E,F was not significant(P0.05).The WBC count in group B reduced,and that in groups D,E,and F increased,indicating statistical differences among them(F=13.07,t=4.32-12.20,P0.05).No significant impairment of functions in liver and kidney was noted in each group.ConclusionTiopronin probably decreases the anti-tumor effect of Oxaliplatin,but appears an obvious protection of liver and kidney." @default.
- W2389875494 created "2016-06-24" @default.
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- W2389875494 date "2011-01-01" @default.
- W2389875494 modified "2023-09-25" @default.
- W2389875494 title "THE EFFECT OF TIOPRONIN COMBINED WITH OXALIPLATIN ON TUMOR:AN EMPIRICAL STUDY" @default.
- W2389875494 hasPublicationYear "2011" @default.
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