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- W2389890604 abstract "Objective To explain how to use Mendelian randomization for reasonable etiological inferences to avoid confounding and reverse causation often seen in observational epidemiological studies. Methods Based on Law of segregation and current information that different genotype leads to changes of intermediate phenotype(standing for certain environmental exposure), gene-disease associations can mimic the impact of exposure on disease, and then deduce the unconfounding associations between exposure and disease Results A causal association between gene and disease can indeed mimic the effect of environmental exposure on the disease. Since the random assortment of alleles at the time of gamete formation,the effect values of genotype-disease will not be distorted by confounding factors,and may reflect the real association between exposure and disease. Conclusion Mendelian randomization principle can strengthen inferences in observational epidemiological studies for well understanding the important etiological factors,as well as provide new approaches for study design and data analysis,so it will be of great prospect." @default.
- W2389890604 created "2016-06-24" @default.
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- W2389890604 date "2006-01-01" @default.
- W2389890604 modified "2023-09-25" @default.
- W2389890604 title "Application of Mendeiian randomization in the etioiogicai study" @default.
- W2389890604 hasPublicationYear "2006" @default.
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