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- W2389896353 abstract "Objective: To explore the relationship between polymorphisms in adiponection and adiponection receptor gene and risk of colorectal cancer.Methods: A total of 370 patients with colorectal cancer and 370 healthy individuals were enrolled in the study,DNA was isolated from 3 ml whole blood obtained from each individuals,and the polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP) was applied to detect the genotype of the polymorphisms in adiponection(rs266729,rs822395,rs822396,rs2241766,rs1501299)and adiponection receptor gene(rs12733285,rs1342387).The frequencies distribution of all genotypes in cancer and control group were compared.Results: There was significant difference of genotype distributions for the polymorphism site(rs12733285) in adiponection receptor gene in the colorectal cancer group(CC 91.89%,CT 8.11%,TT 0.0%)and control group(CC 86.49%,CT 13.51%,TT 0.0%)(χ2=5.61,P=0.018);② There was significant difference distribution of rs1342387 polymorphism in adiponection receptor gene genotypes in cancer group(GG 48.65%,AG 38.92%,AA 12.43%)and control group(GG 37.84%,AG 46.49%,AA 15.68%)(χ2=8.87,P=0.012).③ The CT genotype of rs12733285 was associated with decreased CRC risk(CT versus CC:adjusted OR=0.56,95% CI=0.35-0.91),and the AG and AA genotypes of rs1342387 were associated with decreased CRC risk(AG versus GG: adjusted OR=0.66,95% CI=0.48-0.90;AA versus GG: adjusted OR=0.62,95% CI=0.39-0.98;AG/AA versus GG: adjusted OR=0.65,95% CI=0.48-0.87).④No significant difference of genotype frequencies distribution was observed for the polymorphism sites in adiponection gene between cancer group and control group.Conclusion: Polymorphism sites in adiponection receptor gene(rs12733285、rs1342387) were associated with colorectal cancer risk." @default.
- W2389896353 created "2016-06-24" @default.
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- W2389896353 date "2012-01-01" @default.
- W2389896353 modified "2023-09-26" @default.
- W2389896353 title "Relationship between polymorphism sites of adiponection and it′s receptor gene and the susceptibility of colorectal cancer" @default.
- W2389896353 hasPublicationYear "2012" @default.
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