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- W2389919524 abstract "Aim To investigate the effects of gatifloxacin on liver microsome cytochromes P450 in rats.Methods The Wistar male rats were divided into control group(CG) and gatifloxacin groups.The rats of CG were given saline only and the rats of gatifloxacin groups were administered at 240mg·kg-1(high-dosage group,HG),160mg·kg-1(medial-dosage group,MG) and 80mg·kg-1(low-dosage group,LG) by peritoneal injection (i.p), respectively, qd for seven days.The concentration of protein in liver microsome was determined by the BAC method.The content and activity of cytochrome P450 (CYP450) was detected by spectrophotometer.Results The liver weight and content of CYP450 in rats of gatifloxacin groups were significantly lower than those in CG.The content of cytochrome b5 in rats of treatment groups was increased while the tendency was inhibited by increasing the drug's dosage. Compared with CG,gatifloxacin improved obviously the activity of NADPH-cytochrome C reductase(P0.01) except HG(P0.05).Moreover, there was statistically significant difference between the three treatment groups(P0.05).In terms of the gatifloxacin's effect on erythromycin-N-demethylase and aminopyrine-N- demethylase, the significant difference was exhibited between the treatment groups and control group(P0.01) as well as between the three gatifloxacin groups(P0.05,P0.01). In addition, the hepatic toxicity of gatifloxacin was observed in MG and HG.Conclusion Gatifloxacin affected CYP450 of rats to some extent,and at the same time induced the activity of NADPH-cytochrome C reductase and inhibited that of erythromycin-N-demethylase and aminopyrine-N- demethylase,which could result in the change of metabolism of some medicine by liver drugs enzymes." @default.
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- W2389919524 date "2007-01-01" @default.
- W2389919524 modified "2023-09-25" @default.
- W2389919524 title "The Characteristics Effects of Gatifloxacin on Liver Microsome Cytochrome P_(450) in Rats" @default.
- W2389919524 hasPublicationYear "2007" @default.
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