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- W2389925836 abstract "Objective Diabetic retinopathy(DR) is one of the severe complications of diabetic capillary decreases.Many recent studies support the hypothesis that the retinal inflammatory plays an important role in the early stages of DR.12-Lipoxygenase is a member of lipoxygenases family which can oxygenate polyenoic fatty acids to the form of 12-hydroxyeicosatetraenoic acid,which can up-regulate the level of angiotensin II,participating in the leukostasis,pericapillary cells apoptosis,inducing the chronic oxidative stress and influencing the retinal neovascularization.All of these changes are major processes involved in the pathogenesis of diabetic retinopathy.This article reviews the effect of 12-lipoxygenase on the retinal capillary decreases in the early stages of DR based on the up-to-date international research achievements." @default.
- W2389925836 created "2016-06-24" @default.
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- W2389925836 date "2010-01-01" @default.
- W2389925836 modified "2023-09-23" @default.
- W2389925836 title "Relationship between 12-lipoxygenase and diabetic retinopathy" @default.
- W2389925836 hasPublicationYear "2010" @default.
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