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- W2389945755 abstract "Objective To observe the content changes of superoxide dismutase(SOD) and malondialdehyde(MDA) and discuss the cerebral protective effect of yidalaphon for the patients with acute traumatic brain injury.Methods 48 patients with acute brain trauma in our hospital from December 2010 to December 2012 were randomly divided into observation group(24 cases) and control group(24 cases),the two groups were treated with craniotomy and routine treatment.The observation group was given yidalaphon(30 mg) by intravenous infusion,and completed within half an hour,continuous for 4 days.The concentration of serum SOD and MDA among the treatment(T0),surgery completed(T1),postoperative 2 d(T2),postoperative 2 d(T3),postoperative 4 d(T4) were monitored.Results The two sets of SOD activity was activity increased in T1,T2,T3,T4 compared with T0(P0.05),and the activity of SOD between T1,T2,T3,T4 in observation group were significantly higher than that in the control group(P0.05);the MDA concentration of T1,T2,T3,T4 in the two groups were decreased significantly compared with T0(P 0.05),but MDA concentration of T1,T2,T3,T4 in observation group was significantly lower than that of control group(P0.05).Conclusion Yidalaphon can increase the activity of SOD,decreased the concentration of MDA and it can improves the prognosis of patients with acute traumatic brain injury and their quality of life,it is worth to be applied in clinical." @default.
- W2389945755 created "2016-06-24" @default.
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- W2389945755 date "2013-01-01" @default.
- W2389945755 modified "2023-09-25" @default.
- W2389945755 title "The cerebral protective effect study of yidalaphon for the patients with acute craniocerebral trauma operation" @default.
- W2389945755 hasPublicationYear "2013" @default.
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