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- W2389946124 abstract "Objective: To study relationship betwecn P12A single nucleotide polymorphism in peroxisome proliferator-activated receptors gamma 2( PPAR gamma 2) and type 2 diabetic nephropathy. Methods: According to WHO criteria for diagnosis of diabetes mellitus,the control group( n = 55). Type 2 diabetes mellitus( n = 97). According to urinary albumin excretion in type 2 diabetic nephropathy,morning group( n = 59) and clinical group( 31) were included in this study. These subjects were evaluated for the Pro12Ala single nucleotide poly-morphism in the PPAR gamma 2 using Taqman probe in real-time Q-PCR. Results: A allele frequencies of Pro12Ala mutation of peroxisome proliferator-activated receptors gamma 2( PPAR gamma 2) were 7. 7% 、6. 8% 和 8. 1% in control group and type 2 Diabetic nephropathy. There were no differences in genotype and allele frequencies between those three groups( P 0. 05) 。After adjustment for course of disease were detected evidence for an interactin effect between the Pro12Ala single nucleotide polymorphism and type 2 diabetes using logistic regression,OR = 0. 966,95% confidence interval 0. 279 ~ 3. 344. Between morning group and clinical group A allele frequencies of Pro12Ala mutation of peroxisome proliferator- activated receptors gamma 2( PPAR) were differences about insulin on an empty somach and insulin resistance idindex and insulin sensitivity Index and urinary albumin excretion. Conclusion The Pro12Ala single nucleotide polymorphism of peroxisome proliferator-activated receptors gamma 2 was not associated with diabetic nephropathy. A allele of peroxisome proliferator-activated receptors gamma 2 could precent to progress in type 2 diabeteic nephropathy." @default.
- W2389946124 created "2016-06-24" @default.
- W2389946124 creator A5061431858 @default.
- W2389946124 date "2013-01-01" @default.
- W2389946124 modified "2023-09-23" @default.
- W2389946124 title "ASSOCIATION OF P12A SINGL NUCLEOTIDE POLYMORPHISM IN PEROXISOME PROLIFERATORS-ACTIVATED RECEPTOR-γ2 GENE WITH TYPE 2 DIABETIC NEPHROPATHY" @default.
- W2389946124 hasPublicationYear "2013" @default.
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