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- W2389956972 abstract "Objective To observe effects of resveratrol on the expression of peroxisome proliferator-activated receptor γ(PPARγ) and its downstream signaling molecule activator protein-1(AP-1) in myocardia of rats with high-fat diet.Methods Thirty-two male Sprague-Dawley rats were randomly divided into control(C),high-fat diet(HF),pioglitazone positive(PI),and resveratrol group(RESV) and were fed with normal and high fat diet,respectively.At the same time,PI group and RESV group were treated with 10mg/kg·d body weight pioglitazone,10mg/kg · d body weitgh resveratrol by gavage daily for 6 weeks.PPARγ mRNA was measured by reverse transcription-PCR(RT-PCR).The expressions of PPARγ and AP-1 were detected by western blotting.Results Compared with group C(0.48±0.04),the expression of PPARγ mRNA in HF group(0.36±0.04) was lower(P0.05).Compared with group HF,PPARγ mRNA in RESV group(0.54±0.11) was improved(P0.05).Compared with group C(0.52±0.02),the protein level in group HF(0.40±0.02) was reduced(P0.05),whereas the level of AP-1 protein in group HF was remarkably improved(P0.05).The level of PPARγ in RESV group was improved compared to HF group(P0.05) and the level of AP-1 was reduced(P0.05).Conclusion Resveratrol can activate PPARγ/AP-1 signaling pathway in myocardia in rats with high-fat diet." @default.
- W2389956972 created "2016-06-24" @default.
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- W2389956972 date "2011-01-01" @default.
- W2389956972 modified "2023-09-24" @default.
- W2389956972 title "Effects of resvertrol on PPARγ/AP-1 in heart of rats with high-fat diet" @default.
- W2389956972 hasPublicationYear "2011" @default.
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