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- W2389966098 abstract "Objective To study the effects of lanthanum chloride(LaCl3) on apoptosis and endoplasmic reticulum stressinduced apoptotic pathway in the hippocampus of rats, and discuss the mechanism underlying LaCl3-induced impairment in the hippocampus. Methods A total of 40 Wistar female adult rats were randomly divided into four groups: control, low, moderate and high-dose LaCl3groups. The lactational rats in the low,moderate and high-dose LaCl3groups were given 0.25%, 0.50% and 1.00% LaCl3through drinking water, and control rats were given distilled water. Pups of LaCl3groups were given with LaCl3 by parental lactation and then were administrated with 0.25%, 0.50% and 1.00% LaCl3through drinking water for one month. The hippocampus of pups were collected for all determinations. Cellular apoptotic rate was determined by flow cytometry. Glucose-regulated protein 78(GRP-78), phosphorylated PKR-like endoplasmic reticulum-resident kinase(p-PERK), C/EBPhomologous protein(CHOP), phosphorylated inositol-requiring enzyme 1(p-IRE-1), phosphorylated c-Jun NH2-terminal kinases(p-JNK), caspase-12, caspase-3 and poly ADP-ribose polymerase(PARP) expression levels in the hippocampus were analyzed by Western blotting. Results Cellular apoptotic rates in the hippocampus of three LaCl3groups were significantly higher than that of control group, and showed the dose-effect relationship to a certain extent. GRP-78, p-IRE-1, p-JNK, caspase-12, caspase-3 and PARP expression levels in the hippocampus of low-dose LaCl3group were significantly higher than those of control group. GRP-78, p-PERK, CHOP, caspase-12, caspase-3 and PARP expression levels in the hippocampus of middledose LaCl3group were significantly higher than those of control and low-dose LaCl3groups, and GRP-78, p-PERK, CHOP, pIRE-1, p-JNK, caspase-12, caspase-3 and PARP in the hippocampus of high-dose LaCl3group were significantly higher than those of control and low-, and middle-dose LaCl3groups. Conclusion Enhanced expression of endoplasmic reticulum stressinduced apoptotic pathway may be involved in the mechanism underlying the excessive apoptosis induced by LaCl3in the hippocampus of rats." @default.
- W2389966098 created "2016-06-24" @default.
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- W2389966098 date "2013-01-01" @default.
- W2389966098 modified "2023-09-24" @default.
- W2389966098 title "Effects of lanthanum chloride on endoplasmic reticulum-induced apoptotic pathway in hippocampus of rats" @default.
- W2389966098 hasPublicationYear "2013" @default.
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