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- W2389968018 abstract "ObjectiveTo observe dynamically the express ions of intercellular adh esion molecule-1 (ICAM-1) and P-selectin (Ps) in the vascular endothelium i n rat s with pulmonary thromboembolism (PTE) and the effect of Safflower Injection ( S I). MethodsRats were randomly divided into the normal g roup, the model group a nd the treatment group. PTE model was induced by intravenous injection of auto- b lood clots, and SI was injected intravenously immediately after modelling with 2 ml/(kg·d) for 5 days to the rats in the treatment group. Animals were sacrific ed in batches at the 1st, 3rd, 24th, 72nd and 120th h after embolization to observe the pathological changes and detect the protein and mRNA expressions of ICAM-1 and Ps in pulmonary vascular endothelium by immunohistochemistry and in situ hyb ridization respectively. ResultsPathological observatio n showed obvious emboli sm in pulmonary arteries and inflammatory reaction after modelling, which was ab ated after SI treatment. ICAM-1 and Ps expressions were elevated at the 3rd and th e 1st h after embolization respectively (both P0.01), which a lso were abated in the treatment group. ConclusionSI may alleviate pulmona ry injury in PTE rats by down-regulating the expressions of ICAM-1 and Ps." @default.
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- W2389968018 date "2006-07-01" @default.
- W2389968018 modified "2023-09-24" @default.
- W2389968018 title "[Changes of ICAM-1 and P-selectin in rats with pulmonary thromboembolism and the effect of safflower injection]." @default.
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