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- W2389983439 abstract "Objective This study compared the efficacy and safety of atorvastatin and simvastatin treatment for 8 weeks in hypercholesterolemic Chinese adults.Methods This randomized,open-lable,single center study enrolled the patients with LDL-C≥4.14mmol/L(1.6 g/L) but6.5mmol/L(2.5 g/L) ,and TG4.52mmol/L(4 g/L) after six weeks dietary run-in.Patients were randomized to receive either atorvastatin 20mg/d(A) or simvastatin 20mg/d(S) for 8 weeks.Results Totally 83 patients were included in the study,41 patients in A group and 42 in S group.The TC,LDL-C and TG level decreased and the HDL-C increased significantly after 8 weeks in A group than that in S group.The rate reaching the target level defined by ATPⅢin A group tended to be higher than that in S group(70.73% vs 50%) .The magnitudes of Hs-CRP reduction in A group had significant difference compared to this in S group.There were no drug related SAE found during the study.Conclusions The efficacy of atorvatatin in reducing TC,LDL-C,TG and Hs-CRP is more effective than simvastatin in the same dose,however,the safety data is similar between them in the period of 8 weeks follow-up." @default.
- W2389983439 created "2016-06-24" @default.
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- W2389983439 date "2008-01-01" @default.
- W2389983439 modified "2023-09-24" @default.
- W2389983439 title "Comparison of efficacy and safety of atorvastain versus simvastain in Chinese in a eight-week trial" @default.
- W2389983439 hasPublicationYear "2008" @default.
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