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- W2389988985 abstract "Objective To determine the protection of carvacrol against cerebral ischemia/reperfusion(CI/R) injury in rats by lowing the content of NO. Methods The rats were subjected to CI/R by a thread for middle cerebral artery occlusion(MCAO). After 2 h of cerebral ischemia, the middle cerebral artery was reperfused for 24 h. The rats were randomly divided into 5 groups: a sham group, a model group, and a carvacrol low, middle and high dose group. The neurologic function scores and infarct zone were estimated. The content of NO in the cerebral tissue was also measured by nitrite reduction. Results Compared with the model group, the neurologic function scores and infarct zone in the carvacrol group were significantly decreased(P 0.05). After 24 h CI/R, the content of NO in the cerebral cortex and the hippocampal region of the ischemia and self-control side of model group was significantly more than that of the sham group(P 0.05). The content of NO in the cerebral cortex and the hippocampal region of the ischemia and self-control side of the carvacrol group was significantly less than that of the model group(P 0.05). Conclusion Carvacrol has excellent protective effect against CI/R injury. The mechanism may be related to the content of NO in the cerebral tissue." @default.
- W2389988985 created "2016-06-24" @default.
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- W2389988985 date "2014-01-01" @default.
- W2389988985 modified "2023-09-24" @default.
- W2389988985 title "Carvacrol against cerebral ischemia/reperfusion injury in rats by lowing the content of NO" @default.
- W2389988985 hasPublicationYear "2014" @default.
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