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- W2389995761 abstract "Objective To observe the functional improvement and activities of D 2 receptors in the striatum of hemiparkinsonian monkey receiving the transplant of Alginate-Polylysine-Alginate microencapsulated bovine chromaffin cell (APA-BCC). Methods One hemiparkinsonian monkey was implanted with APA - BCC. After transplantation,behavioral evaluation was performed regularly. A PET study on the hemiparkinsonian monkey with 11 C-raclopride was completed at 48 months post-transplantation. Results In 4 years after transplantation, symptoms of the hemiparkinsonism monkey were relieved and its function recovered almost to normal. Functional image on brain PET with 11 C-raclopride showed that right striatum D 2 receptor activity was higher than that on left striatum at 48 months post-transplantation. Conclusion Encephelic transplantation of APA-BCC can improve the behavior of hemiparkinsonian monkey for a long time, and increase the activity of striatal postsynaptic D 2 receptor in the transplantation area." @default.
- W2389995761 created "2016-06-24" @default.
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- W2389995761 date "2004-01-01" @default.
- W2389995761 modified "2023-09-26" @default.
- W2389995761 title "APA microencapsulated BCC transplantation into hemiparkinsonian monkey:a preliminary observation on activities of D_2 receptors by PET" @default.
- W2389995761 hasPublicationYear "2004" @default.
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