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- W2389997188 abstract "Background and purpose:Combined modalities treatment of limited-stage small cell lung cancer(LS-SCLC) had great progress due to the advance of radiation therapy in recent 20 years.This study was undertaken to analyze the practice process of chemoradiotherapy and to evaluate the outcomes in LS-SCLC treated in our center.Methods:The medical records of SCLC treated at our center between Jan.1997 and Dec.2006 were reviewed retrospectively.LS-SCLC patients were confirmed by pathological diagnosis,and were treated with definitive radiotherapy.The patterns of care and treatment outcomes were investigated.Results:We collected the data of 220 patients with LS-SCLC.Most of the patients received bone scan and brain CT/MRI in initial evaluation.Induction chemotherapy was delivered in 96% of the patients and the median was 2 cycle.Only 5% of the patients received concurrently chemotherapy during radiotherapy.Three-dimensional conformal radiotherapy and intensity modulated radiotherapy were used within 25% of the patients.The median radiation dose was 56 Gy(39-70 Gy),hyperfractionated radiotherapy(1.4 Gy per fraction,twice daily) was used in 58% of the patients.Prophylactic cranial irradiation(PCI) was delivered in 11% of the patients.The median overall survival was 23 months(95%CI: 20-25 months),and the 2-and 5-year overall survival rates were 46% and 22% respectively.Conclusion:The outcomes of LS-SCLC treated in our center were comparable to the results in literature.However,the percentage of the patients treated with concurrently chemoradiotherapy and PCI was low,and the time for radiotherapy should be early in clinical practice." @default.
- W2389997188 created "2016-06-24" @default.
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- W2389997188 date "2012-01-01" @default.
- W2389997188 modified "2023-09-24" @default.
- W2389997188 title "Limited-stage small cell lung cancer treated with chemoradiotherapy: patterns of care and treatment outcomes—10 years' experience" @default.
- W2389997188 hasPublicationYear "2012" @default.
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