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- W2389997488 abstract "Objective: To study the immonotoxicity induced by Benzo(a)pyrene in metallothionein gene knocked mice and compare with that in wild type mice . Methods: Female mice were treated with B(a)P (50 mg/kg body weight, i. p.) and immunized with sheep red blood cells (SRBC) i. v. on the following day and rechallenged by s.c. injection of SRBC into the mouse footpad on day 4 post immunization. Humoral immune function was assessed by spleen IgM antibody plaque formation cells (PFC) to SRBC. Delayed type hypersensitivity (DTH) was measured by footpad swelling response. Results: In MT (-/-) mice, both the spleen weight and PFC per spleen were decreased after B(a)P treatment compared with those in SBRC group, while there were no changes in MT(+/+) mice. The weights of thymus were decreased by B(a)P in both kinds of mice. DTH was not altered by B(a)P in both kinds of mice. Conclusion: MT (-/-) mice are more susceptible to B(a)P induced suppression of humoral immunity. These results indicate that MT plays a role in protecting the mice of against B(a)P induced immunotoxicity." @default.
- W2389997488 created "2016-06-24" @default.
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- W2389997488 date "2001-01-01" @default.
- W2389997488 modified "2023-09-25" @default.
- W2389997488 title "Induction of immunosuppression by benzo(a)pyrene in metallothionein knocked out mice" @default.
- W2389997488 hasPublicationYear "2001" @default.
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