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- W2390000711 abstract "Objective To observe the expression of Nuclear factor-κB(NF-κB)and Transforming growth factor-β1(TGF-β1)in the myocardium and aorta of diabetic rats induced by STZ.Methods 20 male Wister rats were divided into two groups.10 rats without any treatment were served as control group.10 rats were diabetic rats induced by STZ.At 34 weeks,20 male Wister rats were sacrificed for pathological and Immunohistochemical study.The pathological changes were assessed by HE and Masson staining.The expression of cytokines(NF-κB and TGF-β1)in the myocardium and aorta of diabetic rats was assessed with immunohistochemistry.Results In comparison with control group,the expressions of NF-κB and TGF-β1 in the myocardium and aorta of diabetic rats induced by STZ were significantly increased(both P0.01).Conclusions The NF-κB and TGF-β1 may play a critical role in the pathogenesis of the chronic diabetic cardiovascular complications." @default.
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- W2390000711 date "2010-01-01" @default.
- W2390000711 modified "2023-09-24" @default.
- W2390000711 title "The Expression of NF-κB and TGF-β1 in the Myocardium and Aorta of STZ-induced Diabetic Rats" @default.
- W2390000711 hasPublicationYear "2010" @default.
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