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- W2390006990 abstract "Objective To established the menopause aging skin model by ovariectomized of mice and select the drug to anti-skin aging to menopause mice.Methods Female Wister mice were randomly divided into ovariectomized or sham-operated groups,and biochemical analyses were carried out at 50 days after the operation.The dorsal skin samples were collected to determine super oxide dismutase(SOD) activity,malonaldehyde(MDA) and hydroryproline (HYP) content.The morphology of dorsal skins were observed and analyzed under the microscope.Results The content of MDA in the ovariectomy group significantly increased with statistical significance (P0.05),compared with the nomal control group.However,the activity of SOD and HYP content significantly raised which had statistical significance (P0.05).In contrast to the prepration group,thickness of dermis in control group showed significantly reduced and increased content of elastic fibers.Conclusion Ovariectomized mice can be established as the menopause aging skin model." @default.
- W2390006990 created "2016-06-24" @default.
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- W2390006990 date "2010-01-01" @default.
- W2390006990 modified "2023-09-26" @default.
- W2390006990 title "Observation of Skin Appearance of Menopause Mice and Determination of the Correlation Factor" @default.
- W2390006990 hasPublicationYear "2010" @default.
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