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- W2390009092 abstract "OBJECTIVE:To study the pharmacokinetics and relative bioavailability of sparfloxacin lactate tablet in healthy subjects for evaluating the bioequivalency.METHODS:10 healthy volunteers took a single dose(400mg)of sparfloxacin lactate tablets and sparfloxacin tablets(as reference drug) alternately,then the plasma concentrations of sparfloxacin were determined with HPLC.The pharmacokinetic parameters were calculated with 3p87 pharmacokinetic program and the bioequivalency was evaluated.RESULTS:The pharmacokinetic parameters of sparfloxacin lactate tablet and sparfloxacin tablet were:T1/2β=(22.05±1.70)h,(22.23±1.77)h;Cmax=(1.80±0.16)μg/ml,(1.74±0.16)μg/ml;Tmax=(4.11±0.68)h,(3.96±0.80)h;AUCo～t=(49.12±4.53)h/(μg·ml),(45.82±5.32)h/(μg·ml) respectively.The relative bioavailability of sparfloxacin lactate tablet was (107.57±8.47)%.CONCLUSION:Sparfloxacin lactate tablet and sparfloxacin(reference drug)were bioequivalent." @default.
- W2390009092 created "2016-06-24" @default.
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- W2390009092 date "2001-01-01" @default.
- W2390009092 modified "2023-09-25" @default.
- W2390009092 title "Study on the Bioequivalency of Sparfloxacin Lactate Tablet in Man" @default.
- W2390009092 hasPublicationYear "2001" @default.
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