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- W2390012032 abstract "Objective: To observe the effect of tripterygium wilfordii tablets combined tazarotene in the treatment of psoriasis vulgaris in patients.Method: One hundred sixteen cases of psoriasis vulgaris patients were randomly divided into the observation group and the control group,58 cases in each group.Two groups were given topical tacalcitol ointment,bid;0.05% tazarotene gel,1 times a day,before going to bed externally.Observation group was treated with tripterygium wilfordii polyglycoside tablet 30 mg each time,tid.The 2 groups were treated for 4 weeks as 1 courses of treatment.After 3 courses of treatment clinical effect was observed for before and after treatment,including tumor necrosis factor-α(TNF-α),expression of vascular endothelial growth factor(VEGF),interleukin 18(IL-18) and dry skin,itching,erythema,burning and other adverse reaction.Result: In observation group basic recovery rate was 51.72%,total effective rate was 94.83%;in control group the basic recovery rate was 37.93%,the total efficiency of 82.76%.Two groups showed significant basic recovery rate and the total efficiency rate(P0.05).TNF-α,VEGF,IL-18 before and after treatment in 2 groups both showed difference(P0.05).After the treatment,the difference between two groups was significant(P0.05).In observation group the incidence of adverse reactions was 10.34%,in control group the incidence was 8.62% without significant difference.Conclusion: The effect of Tripterygium wilfordii tablets combined tazarotene in the treatment of psoriasis vulgaris has good clinical curative effect,can reduce the level of serum TNF-α,VEGF,IL-18 levels,so that psoriasis patients immune regulation tends to normal,so as to achieve the purpose of treating disease." @default.
- W2390012032 created "2016-06-24" @default.
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- W2390012032 date "2012-01-01" @default.
- W2390012032 modified "2023-09-24" @default.
- W2390012032 title "Effect of Tripterygium Wilfordii Tablets Combined Tazarotene in the Treatment of 58 Cases of Psoriasis Vulgaris" @default.
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