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- W2390031369 abstract "It was reported that atrio peptins possess diuretic, vasodilative, hypo tensive effects and inhibit the release of al dosterone and vasopressin. The effects of synthetic atriopeptin Ⅲ(AP Ⅲ) were studied on the action potential and force of contraction in isolated papillary muscle of guinea pigs as well as slow inward current (Isi) of canine Purkinje fibres.0.1-100 nM APⅢ increased isometric contractile force, action potential duration to 90% repolarization (APD90) and effective refractory period (ERP) in a concentration-dependent manner. At the maximum effect concentraction(by APⅢ 10nM), APD90 and ERP increased by 27.6%, 23 ms and25 ms,respectively. The effects set out at 3 min, reached peak at 10 min, and sustained for 30 min. APⅢ 30 nM increased the peak value of Isi of canine Purkinje fibres by 18.6% of the control.The above mentioned results indicate that AP 1 also possesses a direct action on myocardium. It is of interest that the heart is not only a secretory but also a target organ for atriopeptins, the hormon-like substances." @default.
- W2390031369 created "2016-06-24" @default.
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- W2390031369 date "1988-01-01" @default.
- W2390031369 modified "2023-09-23" @default.
- W2390031369 title "Effects of atriopeptin III on the electrical and mechanical activity in mammalian myocardium" @default.
- W2390031369 hasPublicationYear "1988" @default.
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